When a treatment's clinical issue ...

When a treatment's clinical issue is unknown, adaptive interim analysis can allow accurate calculation of sample size.

When we unfolded the design of a clinical trial protocol to investigate the clinical relevance of a remedy marketed many years ago, calcium dobesilate, for a fresh indication--erectile dysfunction--we did not have available all the information we be in want ofed

Although we started with one encouraging data from in vitro research, no data were available onward its clinical effects. Therefore, we did not have information enough to perform a formal sample size

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