The CPMP's position discouraging dy...

The CPMP's position discouraging dynamic allocation techniques is unfair.

The pair principles underpinning the design, execution, and analysis of comparative clinical trials are minimization of bias and maximization of the precision in estimating treatment meaning Randomization, in conjunction with blinding where possible, is a fundamental tool used in meeting the first of these objectives. (1) Simple (unrestricted) randomization obviates any conscious or unconscious selection bias according to allocating subjects to treatment clusters entirely at random. In the drawn out run it achieves