I have any sympathy with the plea ...

I have any sympathy with the plea according to Marc Buyse and Damian McEntegart ("Achieving Balance in Clinical Trials," May 2004) that it is inappropriate for the EU Regulators to operate a blanket ban forward dynamic allocation methods, not least because I be wrought up that as a general principle guidelines should be as flexible as is possible, consistent with the aim of promoting upright practice. Since there is genuine discussion as regards the competing claims of randomization and minimization, the door should be left spread for both.

However, their confess summary of the controversy is