After expressing our view that the ...

After expressing our view that the European regulators forward the Committee for Proprietary Medicinal works (CPMP) should not "strongly discourage" the use of dynamic randomization techniques, (1) we were delighted to read Professor Senn's commentary which reflected sounded our concerns over excessive regulation of these matters. (2)

We reviewed Professor Senn's commentary with great interest, and be moved that some of his arguments are in ne of a rebuttal. We are well aware that the gain in statistical efficiency derived from the pursuit of balance is extremely unpretending and in our ...

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