There are many publications concern...

There are many publications concerning critical appraisal of medical literature in the present push for the practice of evidence-based medicine. (1) These publications also address the issues of improving the reporting of clinical trial springs (2) and of improving statistical aspects of trial design. (3) There is, however, little published forward the importance of a thorough review of clinical trial protocols to identify potential enigmas prior to their initiation, or onward the issues important for a clinical trial site and its investigators when assessing whether or not to participate