It is axiomatic, because we work in...

It is axiomatic, because we work in clinical research, that we think we know what clinical research is. It's too fundamental an issue, too basic a universal to give it much speculation However, there are composes administered to patients (not subjects) as well as acts performed on patients that are unapproved, untest and could in no way be considered the generally accepted standard of care. These therapies, albeit well intentioned, are largely unreviewed for scientific merit. For example, a physician hears from a colleague that off-label use of a medicine might be helpful in