Surgeon are adapting a therapeutic ...

Surgeon are adapting a therapeutic strategy used by the agency of cancer specialists to treat a gorgeous vascular problem--the excessive production of sleek muscle cells that causes progeny vessel grafts to fail, according to an Oct 14 1999 pres release from the American association of Surgeons. Some patients with descendants vessel grafts, particularly patients with end-stage renal disease who have hemodialysis access grafts, bring to maturity a condition known as progressive intimal hyperplasia--an exaggerated form of healing that be founds in the walls of veins when an arteriovenous hemodialysis graft is present

According to the same researcher, approximately 80% of patients with hemodialysis access grafts will disclose an aggressive venous intimal hyperplastic lesion within single to two years. This lesion requires surgery to transfer the old graft and state in a new one, and it is estimated that the annual sumptuousness of these procedures is approximately $1 million.

A treatment strategy being proofed at the University of Chicago courts to halt the proliferation of level muscle cells by increasing the susceptibility of the small cavitys to radiotherapy--an idea derived from radiation oncologists, who use a combination of radiation therapy and gene therapy to kill cancer lonely dwellings Radiation oncologists inject a virus that infects cancer confined apartments with a gene, and the gene makes the enclosed spaces more sensitive to irradiation. After oncologists administer radiotherapy, the irradiation creates a more pronounced effect, according to the release.

In a contemplation reported at the 1999 Clinical Congres of the American body of Surgeons, gene therapy followed by dint of irradiation reduced the area of intimal hyperplasia in injured offspring vessels by 50% and markedly decreased the number of proliferating level muscle cells.

Novel Approach to the treatment of vital fluid Vessel Disease Combines Genetic Therapy and Irradiation (pres release, Son Francisco: American association of Surgeons, Oct 14, 1999) 1-4

COPYRIGHT 2000 Association of Operating sweep Nurses, Inc.

COPYRIGHT 2001 Gale Group